{"title": "overlake · bio", "logoImg": "bafkreibuepyfa5zwradelsp2xxig2fgz6s6p6n7co5nttd2zriy5yk2bpe", "website": "https://overlake.bio", "bannerImg": "bafkreig4mlbdkxyysiyxk7dp76de5dvjedbnj4zxhitx662nsgijlnu33i", "createdAt": 1743351619742, "credentials": {"twitter": {"type": ["VerifiableCredential"], "proof": {"type": "EthereumEip712Signature2021", "created": "2025-03-30T16:19:23.851Z", "@context": "https://w3id.org/security/suites/eip712sig-2021/v1", "proofValue": "0x51c9016952cee69e08b440c0d8159651faac0277753f9417419118e95212cae95391e4e2bafbcac37be7c34a4a679b57c9831738709a8c7b94bab02b121e39ec1c", "eip712Domain": {"types": {"Proof": [{"name": "@context", "type": "string"}, {"name": "created", "type": "string"}, {"name": "proofPurpose", "type": "string"}, {"name": "type", "type": "string"}, {"name": "verificationMethod", "type": "string"}], "@context": [{"name": "nullifiers", "type": "NullifiersContext"}, {"name": "provider", "type": "string"}], "Document": [{"name": "@context", "type": "string[]"}, {"name": "credentialSubject", "type": "CredentialSubject"}, {"name": "expirationDate", "type": "string"}, {"name": "issuanceDate", "type": "string"}, {"name": "issuer", "type": "string"}, {"name": "proof", "type": "Proof"}, {"name": "type", "type": "string[]"}], "EIP712Domain": [{"name": "name", "type": "string"}], "CredentialSubject": [{"name": "@context", "type": "@context"}, {"name": "nullifiers", "type": "string[]"}, {"name": "id", "type": "string"}, {"name": "provider", "type": "string"}], "NullifiersContext": [{"name": "@container", "type": "string"}, {"name": "@type", "type": "string"}]}, "domain": {"name": "VerifiableCredential"}, "primaryType": "Document"}, "proofPurpose": "assertionMethod", "verificationMethod": "did:ethr:0xd6f8d6ca86aa01e551a311d670a0d1bd8577e5fb#controller"}, "issuer": "did:ethr:0xd6f8d6ca86aa01e551a311d670a0d1bd8577e5fb", "@context": ["https://www.w3.org/2018/credentials/v1", "https://w3id.org/vc/status-list/2021/v1"], "issuanceDate": "2025-03-30T16:19:23.850Z", "expirationDate": "2025-06-28T16:19:23.850Z", "credentialSubject": {"id": "did:pkh:eip155:1:0x59041d70deAEfe849A48E77e0b273DdD072eA9e4", "@context": {"provider": "https://schema.org/Text", "nullifiers": {"@type": "https://schema.org/Text", "@container": "@list"}}, "provider": "ClearTextTwitter#overlake_bio", "nullifiers": ["v0.0.0:KltcCQiei6lgpYRgzsi01s7JYkvuL85lYmwFNmSFu2s="]}}}, "description": "**overlake.bio** is an end-to-end decentralized science (**DeSci**) framework comprising a collection of [projects](https://overlake.notion.site/all-projects-0b1edcacb77e4c93a1b8ad8df47c161d) aimed at promoting human longevity.\n\nThe framework comprises four projects:\n\n**1| [Enzyme engineering for crosslinked collagen turnover](https://overlake.notion.site/Enzyme-engineering-for-crosslinked-collagen-turnover-17f3fc8f169f80079fbfe1fdaed87d0a)**  \nTo design matrix metalloproteinases for extracellular matrix rejuvenation.\n\n**2| [Extracellular matrix aging atlas](https://overlake.notion.site/Extracellular-matrix-aging-atlas-10e0f2ecd2f545afad43fd971cce5be7)**  \nTo assemble a knowledgebase of time-resolved matrisome signatures extracted from public proteomic datasets.\n\n**3| [Advanced glycation end product (AGE)-degrading enzymes](https://overlake.notion.site/Advanced-glycation-end-product-AGE-degrading-enzymes-ce317852187b4639b5e5debe42b62290)**  \nTo engineer biologics to alleviate the glycation load.\n\n**4| [Glycation of ribosomes as a driver of proteostasis loss](https://overlake.notion.site/Glycation-of-ribosomes-as-a-driver-of-proteostasis-loss-d8971d87778846349d8f4fc29a91a30b)**  \nTo produce novel insights into translation fidelity in aging. \\[[preprint](https://dx.doi.org/10.2139/ssrn.4566939)\\]", "logoImgData": {}, "bannerImgData": {}, "projectTwitter": "overlake_bio"}