{"signature": "0x93cd48477e7f6d68645581f8bc254d9a53016dab6f3265cfb2788fd44dee182663b8155bb7f1991489409866dc95deaa02e7c1177a876012b1317f59fbb357231b", "application": {"round": "0xc6bc0ed0bf4675cbf14d1140dcef5415d4e6b0ae", "answers": [{"type": "email", "hidden": true, "question": "Email Address", "questionId": 0, "encryptedAnswer": {"ciphertext": "jY1p/aUvjKQaS4b73nOuHOuKkXmwz2QLiAQoeg05hD2yqB7t7Moc4wtxI/9t52Is", "encryptedSymmetricKey": "d0f77f2efc12c619e6097c2933476059f8f2267bee2676b6b4cd8e42c3d9813403eb005384769f8e33530c93ece24f10a5e547447de235693bbbcb5f15ef5d648d97154dab0fb32375b3de5daa743c7d559ec9f0ab6e5abc4508ab74365ab9a0790f942b14739c297394c0c03428d7b8d22e2bddbda5f11b113306f73ec6422e0000000000000020328e69d3bfeb2d2af91df6d2107c2274411dfab6a84396cd4b3c623fde57fcd84d0d096a888792fa3eb94097f5548da7"}}, {"type": "short-answer", "answer": "Personal funds + Gitcoin rounds", "hidden": false, "question": "Funding Sources", "questionId": 1}, {"type": "number", "answer": "3", "hidden": false, "question": "Team Size", "questionId": 2}, {"type": "short-answer", "answer": "https://github.com/dTrials", "hidden": false, "question": "Github handle (your project GitHub)", "questionId": 3}, {"type": "short-answer", "answer": "@celinmou", "hidden": true, "question": "Telegram handle (of zuzalu representative)", "questionId": 4}, {"type": "short-answer", "answer": "6 months ", "hidden": false, "question": "How old (in Months) is the project?  ", "questionId": 5}, {"type": "paragraph", "answer": "", "hidden": false, "question": "Is there anything else you'd like to share about your project, previous work, or other affiliations? Is there anything else you'd like to add that may help determine project eligibility?", "questionId": 6}, {"type": "short-answer", "answer": "Daniel K / @kosmostasis (X/IG/TG/GitHub)", "hidden": false, "question": "What are the names and social links of your team members?", "questionId": 7}, {"type": "short-answer", "answer": "Both founders attended ZuConnect Istanbul and one (Daniel) co-founder attended Montenegro. Both of us are substantial decision-makers for the tech project.", "hidden": false, "question": "Was at least one core team member at Zuzalu or ZuConnect for at least two weeks? If so, who and at which ones? ", "questionId": 8}, {"type": "paragraph", "answer": "Our platform offers significant value to the Zuzalu community, especially given their interest in longevity and health optimization. By providing a state-of-the-art, privacy-preserving framework for decentralized clinical trials, Zuzalu, and similar network state initiatives can advance in providing advanced health services. This platform, enhanced by blockchain-ready devices from MCS and the underlying protocol will offer an ideal environment for conducting research and trials focused on health optimization and longevity, all while maintaining stringent privacy standards. Our ongoing pilots are crucial for refining this process, ensuring that the community has the perfect platform for their specific research needs in a completely confidential manner.\nWe have supported several Zuzalu gatherings and projects by providing technology tailored to each community's unique needs. Specifically, we have contributed to Vitalia, Zanzalu, Desert Transformation Lab, Ayllu (Venezuela), and the Non-Profit organization LoPH—all stemming from Zuzalu’s community. Additionally, we have been contacted by organizers of various pop-up cities and events, indicating a growing interest and potential for broader application.\nWe are developing infrastructure for data sharing and creating integrable research-ready data. Our work intersects biotech, ZK technology, community gatherings, and blockchain, positioning us to deliver critical insights and foster collaborative research efforts.\n", "hidden": false, "question": "How does your project create value for the Zuzalu ecosystem? ", "questionId": 9}, {"type": "short-answer", "answer": "We have received 0,82 ETH from HackZuzalu’s prize money and 2.564 ETH from the last Gitcoin QF1 round.", "hidden": false, "question": "Have you received any other funding for this project? If so, how much and from what sources?", "questionId": 10}, {"type": "paragraph", "answer": "We have participated in the previous QF round and used the received funds for hardware and software development. We have developed the architectural framework and are working on the private and public key signing feature on the device, ensuring captured data is verified and tamper-proof. We collaborated with MuseMatrix to improve data integrity, an essential part of any decentralized clinical trial. We also ran small-scale pilots in various locations, enhancing our tech stack to address issues around the mobile application and provide communities with the necessary hardware and software for free. Additionally, we started developing in collaboration with CHATAFISHA a data marketplace where trial participants can upload data on-chain, receive NFTs as evidence, and be rewarded for participation.\n", "hidden": false, "question": "Did you participate in a previous Zuzalu Gitcoin round? If so, how did you use those funds?", "questionId": 11}, {"type": "paragraph", "answer": "Next funds will be deployed for further conducting pilots on the ground and adjustment of the hardware and software. The pilots will be crucial for us to understand what is working in a remote setting and to adjust the technology based on community feedback.\n\n- Digital Signature Implementation: We are working on implementing and enhancing digital signing on the device. \n\n- Marketplace and Data Infrastructure: The marketplace and infrastructure for data upload will be further developed. If sufficient funds are available, these components will be developed in parallel.\n\n- Federated Learning Algorithms: On the hardware end, we are working on federated learning algorithms for privacy preservation and decentralized training avoiding the need to share data across all clients.", "hidden": false, "question": "What is your project budget? And if your project is accepted, how will you use the funds from this round? ", "questionId": 12}, {"type": "paragraph", "answer": "From the inception of dTrials, compatibility with Ethereum has been a core principle. We started developing the clinical trial infrastructure on [Zupass during ZuConnect](https://github.com/dTrials/zuhack23), ensuring that it remains ETH-compatible. We continue to pursue this integration.\n\nOur decentralized clinical trial infrastructure, including the marketplace, tokenomics, NFTs, and data-architecture, will be open-source and Ethereum-compatible. This commitment ensures that our platform is aligned with the broader Ethereum ecosystem.\n\n- Marketplace and Tokenization: Both the marketplace and tokenization (including NFTs) will be compatible with Ethereum.\n- Integration with Zupass: Our technology is integrated with Zupass, ensuring seamless interaction within the ecosystem.\n- Digital Signature and Marketplace: The digital signature feature on the device and the marketplace we intend to develop will also be open source.\n- Hardware Technology: While the hardware technology (MCS smartwatches) for data collection will not be open source, all other components will be.\n \nThe project’s idea was piloted during ZuConnect, involving three attendees and integrating ZuPass to create a \"proof of participation\" in the pilot dTrial without revealing their personal information or identity.\n", "hidden": false, "question": "Is your blockchain-facing tech maximally compatible with Ethereum and common Ethereum ecosystem standards(https://ethereum.org/en/developers/docs/standards/)? If so, how? ", "questionId": 13}, {"type": "short-answer", "answer": "Only the hardware is closed source as this is propietary to MCS smart watch. The infrastructure of the decentralized trials, the market place, NFT, tokenomics and the digital signing are all OS", "hidden": false, "question": "Is your project open source? If any code is a closed source, why? ", "questionId": 14}, {"type": "short-answer", "answer": "Yes", "hidden": false, "question": "Do you agree by January 1st, 2025 to declare how the funds were used via Zuzagora or its successor? ", "questionId": 15}, {"type": "short-answer", "answer": "A lot of people inside and outside the community are helping us to realize dTrials: MCS Data Labs: Responsible for the hardware and software ecosystem to collect health and environmental data in the most privacy-preserving fashion. Kosmostasis Labs: Developing the protocol open-source layer for the marketplace and infrastructure for decentralized clinical trials. They are also responsible for conducting on-the-ground experiments within Zuzalu communities and beyond. LoPH: A Non-Profit organization with the project \"Decentralized Rights to Breathe,\" supporting decentralized data storage and creating infrastructure for decentralized data collection. They are also developing NFTs for evidence capture and user participation. ChataFisha: Supporting marketplace development with their expertise in developing decentralized infrastructures for impact evaluation, NFTs, and tokenomics.  MuseMatrix: Collaborating with us on the digital signature feature for the device. These collaborations are essential to achieving our goal of creating a comprehensive and decentralized clinical trial platform, leveraging the strengths of each partner to enhance our technology and ensure its successful deployment.", "hidden": false, "question": "How could your project interoperate with other Zuzalu projects? ", "questionId": 16}, {"type": "link", "hidden": false, "question": "If your project is a working product, share a link to a demo video ", "questionId": 17}, {"type": "paragraph", "hidden": false, "question": "Write out your roadmap if not already included in your project description", "questionId": 18}], "project": {"id": "0x3ea76df88c43bd2c64eb67c4e308e7a79ebe044190929accb4a573424dad9c1b", "title": "dTrials", "logoImg": "bafkreidjzg2t3lcnrbo2wekrp6cs74qapqjn4yy5mybadeo5wjcfdeiqha", "metaPtr": {"pointer": "bafkreics3yycv7d732cyqb66rthfrygj42zbbcshqdyjis36ts46j7lgwu", "protocol": "undefined"}, "website": "https://dtrials.gitbook.io/dtrials", "bannerImg": "bafkreicgakip235cr4rprlyukmudwe3zut37dp55u232dvjmlbxmvfuwgi", "createdAt": 1721223778706, "userGithub": "mousacel", "credentials": {}, "description": "**TL;DR:** dTrials is a hardware and software stack for distributed to fully decentralized clinical trials.\n \n# Vision\nIn an era where technology is reshaping healthcare, our team proposes an innovative approach to revolutionize clinical trials. Our vision is to create a new paradigm in clinical trials - one that is more inclusive, equitable, and efficient. By decentralizing the research process and employing innovative technologies, we strive to open up new avenues for scientific discovery and healthcare advancements, making clinical research accessible to all.\n \n# Issue Statement\nOur project addresses several pivotal challenges in clinical trials:\n\n- Data Accessibility and Utilization: Real-world health data is often trapped in isolated silos, impeding its use in health innovation and research due to organizational, legal, and technical barriers.\n\n- Participant Engagement and Compliance: Low engagement and compliance in clinical trials result in incomplete or biased data.\n\n- Trial Accessibility: Traditional trials face geographical and logistical barriers that restrict diverse population participation.\n\n- Data Privacy Concerns: Convincing participants to share personal health data remains a significant hurdle due to privacy concerns.\n\nBy introducing a decentralized model for clinical trials and enabling direct data sharing from individuals, we aim to enhance data collection efficiency, improve participant engagement, and foster more inclusive and diverse research.\n \n# Solution\nOur proposed solution integrates advanced technology and a decentralized approach to address key challenges in clinical trials. It encompasses:\n\n- Advanced Technology Integration: Utilizing MCS Data Labs' proprietary smartwatches equipped with sensors for comprehensive bio and environmental data collection, supported by custom software and AI/XAI algorithms for efficient data capture and processing.\n\n- Decentralized Clinical Trials Infrastructure: Creating an open-source platform to democratize the research process, allowing diverse groups to conduct their own clinical trials.\n\n- Privacy and Data Sovereignty: Incorporating Web3 technologies like sharding and ZK proofs to ensure enhanced privacy and data security, giving users complete control over their data.\n\n- Tokenomics for Participant Compliance: Introducing a tokenomics model to incentivize participants through smart contracts, promoting adherence to trial protocols.\n\n- Community-Driven Research Ecosystem: Implementing a DAO structure to allow community members, including patients and researchers, to actively participate in the research process, fostering a democratic, privacy-preserving approach.\n \n# Background\nOur journey began at the ZuHack event in Istanbul last November, where we focused on enhancing the privacy aspects of our technology and conducted a small-scale pilot with MCS’s proprietary smart devices. Our innovative approach won two awards in the DeSci and ZK categories, validating our initial hypotheses and setting the foundation for our ongoing work. \n\nMore details on our submission can be found on the [DoraHacks project page](https://dorahacks.io/buidl/7963) and on [our repository from that hack](https://github.com/dTrials/zuhack23).\n \n\n\n** Please explain how your project meets the round-specific eligibility criteria.**\n\nBoth founders attended ZuConnect Istanbul and one co-founder attended Montenegro. Both of us are substantial decision-makers for the tech project.\n**Other sources of funding**\nWe have received 0,82 ETH from HackZuzalu’s prize money and 2.564 ETH from the last Gitcoin QF1 round.\n\n\n**Past Achievements**\n\nWe have participated in the previous QF round and used the received funds for hardware and software development. We have developed the architectural framework and are working on the private and public key signing feature on the device, ensuring captured data is verified and tamper-proof. We collaborated with MuseMatrix to improve data integrity, an essential part of any decentralized clinical trial. We also ran small-scale pilots in various locations, enhancing our tech stack to address issues around the mobile application and provide communities with the necessary hardware and software for free. Additionally, we started developing in collaboration with CHATAFISHA a data marketplace where trial participants can upload data on-chain, receive NFTs as evidence, and be rewarded for participation.\n \n\n**Value for Zuzalu ecosystem** \n\nOur platform offers significant value to the Zuzalu community, especially given their interest in longevity and health optimization. By providing a state-of-the-art, privacy-preserving framework for decentralized clinical trials, Zuzalu, and similar network state initiatives can advance in providing advanced health services. This platform, enhanced by blockchain-ready devices from MCS and the underlying protocol will offer an ideal environment for conducting research and trials focused on health optimization and longevity, all while maintaining stringent privacy standards. Our ongoing pilots are crucial for refining this process, ensuring that the community has the perfect platform for their specific research needs in a completely confidential manner.\n\nWe have supported several Zuzalu gatherings and projects by providing technology tailored to each community's unique needs. Specifically, we have contributed to Vitalia, Zanzalu, Desert Transformation Lab, Ayllu (Venezuela), and the Non-Profit organization LoPH—all stemming from Zuzalu’s community. Additionally, we have been contacted by organizers of various pop-up cities and events, indicating a growing interest and potential for broader application.\n\nWe are developing infrastructure for data sharing and creating integrable research-ready data. Our work intersects biotech, ZK technology, community gatherings, and blockchain, positioning us to deliver critical insights and foster collaborative research efforts.\n \n\n**Ethereum compatibility and OSS:**\n\nFrom the inception of dTrials, compatibility with Ethereum has been a core principle. We started developing the clinical trial infrastructure on [Zupass during ZuConnect](https://github.com/dTrials/zuhack23), ensuring that it remains ETH-compatible. We continue to pursue this integration.\n\nOur decentralized clinical trial infrastructure, including the marketplace, tokenomics, NFTs, and data-architecture, will be open-source and Ethereum-compatible. This commitment ensures that our platform is aligned with the broader Ethereum ecosystem.\n\n- Marketplace and Tokenization: Both the marketplace and tokenization (including NFTs) will be compatible with Ethereum.\n\n- Integration with Zupass: Our technology is integrated with Zupass, ensuring seamless interaction within the ecosystem.\n\n- Digital Signature and Marketplace: The digital signature feature on the device and the marketplace we intend to develop will also be open source.\n\n- Hardware Technology: While the hardware technology (MCS smartwatches) for data collection will not be open source, all other components will be.\n \nThe project’s idea was piloted during ZuConnect, involving three attendees and integrating ZuPass to create a \"proof of participation\" in the pilot dTrial without revealing their personal information or identity.\n \n\n**Future Steps**\n\nNext funds will be deployed for further conducting pilots on the ground and adjustment of the hardware and software. The pilots will be crucial for us to understand what is working in a remote setting and to adjust the technology based on community feedback.\n\n- Digital Signature Implementation: We are working on implementing and enhancing digital signing on the device. \n\n- Marketplace and Data Infrastructure: The marketplace and infrastructure for data upload will be further developed. If sufficient funds are available, these components will be developed in parallel.\n\n- Federated Learning Algorithms: On the hardware end, we are working on federated learning algorithms for privacy preservation and decentralized training avoiding the need to share data across all clients.\n\n \n**Collaborations**\n\nA lot of people inside and outside the community are helping us to realize dTrials:\n\n- MCS Data Labs: Responsible for the hardware and software ecosystem to collect health and environmental data in the most privacy-preserving fashion.\n\n- Kosmostasis Labs: Developing the protocol open-source layer for the marketplace and infrastructure for decentralized clinical trials. They are also responsible for conducting on-the-ground experiments within Zuzalu communities and beyond.\n\n- LoPH: A Non-Profit organization with the project \"Decentralized Rights to Breathe,\" supporting decentralized data storage and creating infrastructure for decentralized data collection. They are also developing NFTs for evidence capture and user participation.\n\n- CHATAFISHA: Supporting marketplace development with their expertise in developing decentralized infrastructures for impact evaluation, NFTs, and tokenomics. \n\n- MuseMatrix: Collaborating with us on the digital signature feature for the device.\n\nThese collaborations are essential to achieving our goal of creating a comprehensive and decentralized clinical trial platform, leveraging the strengths of each partner to enhance our technology and ensure its successful deployment.\n", "lastUpdated": 0, "projectGithub": "dTrials"}, "recipient": "0x374251904e35b37725E7609B24320799EF081bC0"}}